Inhibition ofMycobacterium tuberculosisTransaminase BioA by Aryl Hydrazines and Hydrazides
نویسندگان
چکیده
منابع مشابه
Synthesis, biological evaluation and molecular docking of aryl hydrazines and hydrazides for anticancer activity.
Aryl hydrazine and hydrazide analogues were synthesized based on p-tolyl hydrazine, isolated as a breakdown product of a secondary metabolite from the mushroom, Agaricus bisporus, and tested to be highly active molecule than 5-fluorouracil in in vitro anticancer studies. The synthesized analogues were tested for anticancer activity using NCI protocol. Anolgues 12 and 15 emerged as molecules wit...
متن کاملAsymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines
The asymmetric synthesis of N-allylic indoles is important for natural product synthesis and pharmaceutical research. The regio- and enantioselective N-allylation of indoles is a true challenge due to the favourable C3-allylation. We develop here a new strategy to the asymmetric synthesis of N-allylic indoles via rhodium-catalysed N-selective coupling of aryl hydrazines with allenes followed by...
متن کاملA palladium-catalyzed reaction of aryl halides, potassium metabisulfite, and hydrazines.
Aryl N-aminosulfonamides could be easily produced via a palladium-catalyzed coupling of aryl halides, potassium metabisulfite, and hydrazines. Potassium metabisulfite is an excellent equivalent of sulfur dioxide in the reaction of palladium-catalyzed aminosulfonylation.
متن کاملAcyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones.
In this communication we describe a novel strategy for the formation of valuable diaryl and aryl alkyl ketones from acyl hydrazides. A wide variety of ketones are prepared and the mild reaction conditions allow for the use of a range of functionalities, especially in the synthesis of diaryl ketones.
متن کاملInhibition of the alanine-alpha-oxoglutaric acid transaminase of pig-heart muscle by cyclic hydrazides.
8oNicotinic acid hydrazide (isoniazid) has antituberculous activity both in vivo and in vitro (Fox, 1951). In man its principal toxic effect, peripheral neuritis (Biehl & Vilter, 1954; Oestreicher, Dressler & Middlebrook, 1954), can be prevented by the concurrent administration of vitamin B. (pyridoxine) (Biehl & Vilter, 1954; Biehl & Nimitz, 1954). It is of interest to discover whether the spe...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2014
ISSN: 1439-4227
DOI: 10.1002/cbic.201300748